Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials - 9783030495305

This book provides an extensive overview of the principles and methods of sample size calculation and recalculation in clinical trials. Blinded sample size recalculation procedures for internal pilot study designs are considered, as well as methods for sample size reassessment in adaptive designs that use unblinded data from interim analyses.

• | : Meinhard Kieser
• | Publisher: Springer Nature Switzerland AG
• | Publication Date: Nov 20, 2021
• | Country of Publication: Switzerland
• | Number of Pages: 396 pages
• | Language: Unknown
• | Binding: Paperback / softback
• | ISBN-10: 3030495302
• | ISBN-13: 9783030495305